Purified anti-mouse TCR Vbeta8.1, 8.2

The TCR Vbeta 8 family consists of three members, namely Vbeta8.1, 8.2 and 8.3. KJ16-133.18 reacts with Vbeta8.1, 8.2 only, but not Vbeta8.3. Most mouse strains have about 20% Vbeta 8+ T cells in the periphery.However, C57BR, C57L, SJL, SWR (Tcra haplotype) and RIII strains (Tcrc haplotype) do not express Vbeta8 due to a gene deletion at the Vbeta 8 family loci.Other strains expressing endogenous super-antigen, such as Mls-1a have significant reduced number of Vbeta 8.1 cells in the periphery.Exogenous superantigen, such as staphylococcal enterotoxin B, stimulates lymphocytes bearing Vbeta 8 and selectively eliminate those T cells in vivo.

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SPECIFICATIONS

Catalog Number

118402

Size

100 microg

Applications

FC, IP

Hosts

Rat

Reactivities

Mouse

Clone

KJ16-133.18

Antigen

TCR receptor from T cell hybridoma DO-11.10

Gene Id

21577

Isotype

Rat IgG2a, kappa

Clonality

Monoclonal

Dilutions

*: Each lot of this reagent has been quality control titrated. For immune-fluorescent staining the suggested use of this reagent is ? 0.25 microg per million cells in 100 microl volume. Recommend to titrate for optimal performance.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C.

Alternative Names

T cell receptor Vb8.1, 8.2 chain, TCR Vb8.1, 8.2

Regulatory Status

RUO