Purified anti-mouse IL-23 (p19)

Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12.IL-23 is secreted by activated macrophages and dendritic cells.Human and mouse p19 share 70% aa sequence identity. The functional IL-23 receptor complex consists of two receptor subunits, a beta1 subunit shared with the IL-12 receptor (IL-12R beta1) and a beta2-like subunit with STAT4 binding domain, termed the IL-23-specific receptor subunit (IL-23R).IL-23 has been shown to enhance IFN-gamma production by memory T cells.Additionally, mouse IL-23 (but not IL-12) can activate mouse memory T cells to produce the potent proinflammatory cytokine IL-17.IL-23 has been shown to be upregulated in certain autoimmune diseases and promote immunity in response to some viral and mycobacterial infections.

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SPECIFICATIONS

Catalog Number

513801

Size

50 microg

Applications

IF

Hosts

Mouse

Reactivities

Mouse

Clone

MMp19B2

Antigen

Mouse p19 C-terminal peptide

Gene Id

83430

Isotype

Mouse IgG2b, kappa

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by ELISA assay. For use as an ELISA capture antibody, a concentration range of 2-6.0 microg/ml is recommended. To obtain a linear standard curve, serial dilutions of IL-23 recombinant protein ranging from 2000 to 8 pg/ml are recommended for each ELISA plate. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C.

Alternative Names

Interleukin-23 p19

Regulatory Status

RUO