Purified anti-mouse/human Helios

Helios is a member of the Ikaros family of zinc finger transcription factors. It contains a C-terminal region composed of 2 zinc-finger domains that mediate dimerization between the family members. Helios was originally cloned from a mouse thymoma line. It is mainly expressed in peripheral T cells and thymocytes. It is found at high levels in a subpopulation of regulatory T cells. Helios plays an important role in T cell development and homeostasis. Overexpression of Helios profoundly alters alphabeta T cell differentiation and activation. It has been determined that silencing of Helios in B cells is critical for maintaining normal B cell function. Helios is involved in tumor immunity.

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SPECIFICATIONS

Catalog Number

137202

Size

100 microg

Applications

FC, ICC

Reactivities

Hum, Mouse

Clone

22F6

Antigen

Helios peptide (aa 51-107)

Gene Id

22779,22807

Isotype

Armenian Hamster IgG

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by intracellular flow cytometry using our FOXP3 Fix/Perm protocol. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C.

Regulatory Status

RUO