Purified anti-mouse CD152

CD152 is a 33 kD member of the immunoglobulin superfamily also known as CTLA-4 or Ly-56. It is expressed on activated T and B lymphocytes. CD152 is similar to CD28 in amino acid sequence, structure, and genomic organization and these two receptors share common B7 family counter-receptors (B7-1, B7-2). Whereas CD28 delivers a costimulatory signal in T cell activation, CTLA-4 negatively regulates cell-mediated immune responses. CD152 is thought to play a role in the induction and maintenance of immunological tolerance, as well as the development of protective immunity and thymocyte regulation. The 9H10 antibody can enhance T cell co-stimulation by blocking CTLA-4 interactions with the B7 co-receptors, favoring CD28 interactions.

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SPECIFICATIONS

Catalog Number

106202

Size

500 microg

Applications

ELISA, FC

Hosts

Ham

Reactivities

Mouse

Clone

9H10

Antigen

Mouse CTLA-4-human IgG1 fusion protein

Gene Id

12477

Isotype

Syrian Hamster IgG

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by ELISA assay. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C.

Alternative Names

Cytotoxic T Lymphocyte-Associated Antigen-4, CTLA-4, Ly-56

Regulatory Status

RUO