Purified anti-mouse CD124 (IL-4Ralpha)

CD124, a subunit of IL-4R, is a 140 kD transmembrane glycoprotein. It associates with either the common gamma-chain (CD132) to form the type I IL-4R complex, which specifically binds IL-4, or with IL-13Ra1 to form the type II IL-4R heterodimeric complex, which binds and transduces signals from either IL-4 or IL-13. A truncated form of IL-4Ralpha exists in soluble form in biological fluids. CD124 is expressed on mouse late precursors and mature B-cells, T-cells, monocytes, and has low expression on granulocytes. In B cells, CD124 can bind with IL-4 and IL-13 to regulate IgE antibody production. In T cells, the type I IL-4R (IL-4R/gC) is mostly responsible for Th2 cell expansion by mediating IL-4-dependent activation of the transcription factors in hematopoietic cells. The type II IL-4R (IL-4R/IL-13Ra1) is the main route for nonhematopoietic cell responses to IL-4 or IL-13.