Purified anti-Lyn

Lyn is a tyrosine protein kinase and a member of the src subfamily. Two isoforms of Lyn have been reported: Lyn A, 53 kD and Lyn B, 56 kD. Lyn is predominantly expressed in macrophages, B cells, and platelets. Lyn exhibits both stimulatory activity (mast cells) and inhibitory activity (B cells), and has been shown to increase p53 levels and inhibit nuclear export. Recent reports have suggested that Lyn may participate in the induction of apoptosis by genotoxic agents. Lyn has been shown to be activated in late G1 by stem cell factor and is increased in myeloid leukemias. Lyn interacts with the high affinity IgE receptor, actin cytoskeleton, gamma-tubulin, and p53. The LYN-01 monoclonal antibody recognizes the human, mouse, and rat Lyn and has been shown to be useful for Western blotting, immunoprecipitation, and immunocytochemistry.

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SPECIFICATIONS

Catalog Number

628102

Size

100 microg

Applications

ICC, IP, WB

Hosts

Mouse

Reactivities

Hum, Mouse, Rat

Clone

LYN-01

Antigen

Partial recombinant Lyn (aa 8-238) expressed in bacteria

Gene Id

4067

Isotype

Mouse IGg1, kappa

Clonality

Monoclonal

Dilutions

Each lot of this antibody has been quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 5 microg per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C.

Alternative Names

Tyrosine protein kinase Lyn

Regulatory Status

RUO