Purified anti-LEF1

Lymphoid Enhancing Factor 1 (LEF1) is a transcription factor belonging to the TCF/LEF family. LEF1 was first identified as a protein binding to TCR-alpha enhancer and upregulates expression of T-cell antigen receptor alpha chain. LEF1 is involved in Wnt signaling pathways as a ubiquitous regulator. During Wnt signaling, translocation of beta-catenin from the cytosol to the nucleus results in elevation of transcriptional activity of LEF1, which subsequently regulates multiple downstream genes.

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SPECIFICATIONS

Catalog Number

653102

Size

100 microg

Applications

FC, ICC, WB

Hosts

Mouse

Reactivities

Hum

Clone

15H5A18

Antigen

Partial human LEF1 recombinant protein (1-298 aa)

Gene Id

51176

Isotype

Mouse IgG1, kappa

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1-0.5 microg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

Upon receipt, store undiluted at 4C.

Alternative Names

lymphoid enhancer-binding factor 1, T cell-specific transcription factor 1-alpha (TCF1-alpha), TCF10, LEF-1, TCF1ALPHA, TCF7L3

Regulatory Status

RUO