Purified anti-LAT

LAT is a transmembrane molecule that mediates signaling following the engagement of a number of cell surface receptors including TCR during mature T cell activation, pre-TCR during T cell development, Fc RIII on NK cells, and FcepsilonRI on mast cells.LAT is multiply phosphorylated on tyrosines by ZAP-70 and Syk, which leads to downstream effects that include release of intracellular calcium, PKC activation, MAPK activation and cytoskeletal reorganization.Palmitoylation of LAT is required for its localization to lipid rafts and efficient phosphorylation.

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SPECIFICATIONS

Catalog Number

641101

Size

25 microg

Applications

IP, WB

Hosts

Mouse

Reactivities

Hum, Mouse

Clone

11B.12

Antigen

GST fusion protein corresponding to residues 31-233 of human LAT, cytoplasmic domain.

Gene Id

27040

Isotype

Mouse IgG1, kappa

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 5 microg antibody per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

Upon receipt, store at 4C

Alternative Names

Linker for activation of T cells

Regulatory Status

RUO