Purified anti-human Tim-1

Tim-1 is a transmembrane glycoprotein expressed on activated CD4+ lymphocytes especially on Th2 cells. It has been implicated to play a critical role in the development of atopic disease and other Th2-biased immune responses. Tim-1 is hepatitis A virus receptor in humans. Tim-4 is the endogenous ligand of Tim-1. The interaction of Tim-1 and Tim-4 is involved in costimulation of T cell proliferation. Recently, Tim-1 has been reported to be an endogenous ligand for LMIR5 (Leukocyte mono-immunoglobulin (Ig)-like receptor 5), and the Tim-1-LMIR5 interaction plays a physiological role in immune regulation by myeloid cells.

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SPECIFICATIONS

Catalog Number

353901

Size

25 microg

Applications

FC

Hosts

Mouse

Reactivities

Hum

Clone

1D12

Antigen

Human TIM-1-IgV Fc

Gene Id

26762

Isotype

Mouse IgG1, kappa

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?1.0 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C.

Alternative Names

T cell immunoglobulin mucin 1, kidney injury molecule-1, HAVCR, TIM; KIM1; TIM1; KIM-1; TIMD1; TIMD-1; HAVCR-1

Regulatory Status

RUO