Purified anti-human RANTES

RANTES is a 7.8 kD member of the CC family of chemokines, also known as CCL5, which is expressed in T cells and monocytes/macrophages. RANTES is strongly chemotactic for monocytes/macrophages, memory T cells, eosinophils, and induces histamine release from basophils. In solution, RANTES can form high molecular weight aggregates that exhibit dissimilar biological activities to the dimeric form. Aggregates cause T cell and neutrophil activation while promoting HIV infection, whereas, the dimeric form exhibits RANTES-induced chemotaxis and inhibits HIV infection. Interestingly, as T cells become activated RANTES secretion appears to decrease.

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SPECIFICATIONS

Catalog Number

510201

Size

50 microg

Hosts

Mouse

Reactivities

Hum

Clone

BL-5030

Antigen

Recombinant human RANTES

Gene Id

6352

Isotype

Mouse IgG1, kappa

Clonality

Monoclonal

Dilutions

Each lot of this protein is quality control tested by ELISA assay. For ELISA capture applications, a concentration range of 0.5-2 microg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C.

Alternative Names

Normal T cell Expressed and Secreted (RANTES), sisdelta, CCL5

Regulatory Status

RUO