Purified anti-human IL-33

IL-33, also known as NFHEV and DVS 27, is a 30 kD proinflammatory protein that belongs to IL-1 superfamily. IL-33 is constitutively expressed in smooth muscle and airway epithelia. It is upregulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL1alpha or IL1beta stimulation. IL-33 interacts with IL1RL1/ST2 receptor and IL-1 receptor accessory protein (IL1RAP) in order to activate intracellular molecules in the NF-kappaB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. Recombinant IL-33 has been shown to enhance Th2-associated immune responses and potently increase mast cell proliferation and cytokine production.

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SPECIFICATIONS

Catalog Number

517202

Size

100 microg

Applications

WB

Hosts

Mouse

Reactivities

Hum

Clone

BL35172

Antigen

Mature recombinant protein human Interleukin-33 (Ser112-Thr270)

Gene Id

90865

Isotype

Mouse IgG1, kappa

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. For Western blotting applications, a concentration of 1 microg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

Upon receipt, store undiluted at 4C.

Alternative Names

Interleukin 33, IL33, DV27, C9ORF26, IL1F11 (Interleukin-1 Family Member 11), NFHEV (Nuclear factor from high endothelial venules)

Regulatory Status

RUO