Purified anti-human Factor H

Factor H, a 155 kD soluble glycoprotein, is a member of the regulators of complement activation family and is a complement control protein. It circulates in human plasma at a concentration of 500–800 mg/ml that provides critical negative regulation to the alternative pathway of complement cascade. Factor H is secreted by Kupffer cells, hepatocytes, vascular endothelial cells, and platelets. Overactive factor H may result in reduced complement activity on pathogenic cells, increasing susceptibility to microbial infections. Underactive factor H may result in increased complement activity on healthy host cells, resulting in autoimmune diseases.

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SPECIFICATIONS

Catalog Number

518402

Size

500 microg

Applications

WB

Hosts

Mouse

Reactivities

Hum

Clone

C18/3

Antigen

Human Complement Factor H

Gene Id

3075

Isotype

Mouse IgG1, kappa

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by ELISA assay. For ELISA capture applications, a concentration range of 2-8 microg/ml is recommended. To obtain a linear standard curve, serial dilutions of Factor H recombinant protein ranging from 78 to 5000 pg/ml are recommended for each ELISA plate. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C.

Alternative Names

Complement Factor H

Regulatory Status

RUO