Purified anti-human CD344 (Frizzled-4)

CD344 is a member of the Frizzled family, known as Frizzled-4 (Fz4, FZD4, hFz4, or FzE4). Ten frizzled member have been identified in humans. Human FZD4 gene has been mapped to chromosome 11q14-q21. FZD4 is a 48-53 kD seven transmembrane G-protein-coupled receptor (GPCR), a receptor for Wnt proteins and norrie. It is involved in the activation of Wnt/beta-catenin pathway (canonic Wnt signaling). FZD4 is a neuronal stem cell marker and is also expressed on fetal neuronal progenitor cells and neuronal intestinal cells. Kidney, lung, brain and liver express abundant of FZD4. It has been reported that FZD4 controls retinal and inner ear angiogenesis, participates in the regulation of embryonic development, tissue and cell polarization and proliferation.

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SPECIFICATIONS

Catalog Number

326601

Size

25 microg

Applications

FC

Hosts

Mouse

Reactivities

Hum

Clone

CH3A4A7

Antigen

WERI-RB-1 retinoblastoma cells

Gene Id

8322

Isotype

Mouse IgG1, kappa

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ? 2.0 microg per 106 cells in 100 microl volume or 100 microl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C.

Alternative Names

Frizzled-4 receptor, Frizzled-4, Fz4, FZD4, FzE4, hFz4, FEVR, EVR1

Regulatory Status

RUO