Purified anti-human CD328 (Siglec-7)

Siglec-7 is a 75 kD type I transmembrane protein and a member of the family of sialic acid-binding immunoglobulin-like lectins (Siglecs), also known as p75/AIRM1. It is primarily found on NK cells and monocytes. The cytoplasmic domain of Siglec-7 contains immunoreceptor tyrosine-based inhibitory motif (ITIM). CD328 mediates sialic acid-dependent cell-cell binding and functions as an inhibitory receptor of NK cells. CD328 preferentially binds to sialylated glycans with alpha2,8 disialyl and alpha2,6 sialyl residues.

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SPECIFICATIONS

Catalog Number

347702

Size

100 microg

Applications

FC, IP

Hosts

Mouse

Reactivities

Hum

Clone

S7.7

Antigen

Siglec-7 3T3 transfected cells

Gene Id

27036

Isotype

Mouse IgG1, kappa

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?0.5 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C.

Alternative Names

QA79 membrane protein, Adhesion inhibitory receptor molecule 1, p75/AIRM1, D-siglec

Regulatory Status

RUO