Purified anti-human CD307e (FcRL5)

FcRL5, also known as CD307e, CD307, IRTA2, FcRH5 and BXMAS1, is a 106kD type I transmembrane glycoprotein composed of 6-8 extracellular Ig like C2 domains and 2 cytoplasmic ITIM motifs. The FcRL5 gene is located on chromosome 1q21 and is normally expressed by tonsillar plasma cells and germinal center B cells. It has been suggested that FcRL5 contributes to B cell maturation and B cell receptor modulation. The identification of FcRL5 on a number of transformed cell types including hairy cell leukemia, mantle cell lymphoma, chronic lymphocytic lymphoma and Burkitt’s lymphoma has prompted interest in it as a potential biomarker or target for immunotherapy. FcRL5 binds all aggregated IgG isotypes.

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SPECIFICATIONS

Catalog Number

340302

Size

100 microg

Applications

FC, IP

Hosts

Mouse

Reactivities

Hum

Clone

509f6

Antigen

P815 cells transfected with FcRL5

Gene Id

83416

Isotype

Mouse IgG2a, kappa

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?0.125 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C.

Alternative Names

CD307, IRTA2, FcRH5, IFGP5, BXMAS1

Regulatory Status

RUO