Purified anti-human CD254 (TRANCE, RANKL)

Human RANKL (receptor activator of NF-kB ligand), also known as TRANCE (TNF-related activation-induced cytokine receptor) and OPGL (Osteoprotegerin ligand), and CD254, is a type II transmembrane protein in theTNF superfamily. It has two forms - a membrane-anchored protein and a secreted protein. Its extracellular domain is related to TRAIL, FasL, and TNF. TRANCE is expressed on osteoclasts and activated T cells. It has been implicated in the regulation of T cell and dendritic cell interactions. RANKL plays an important role in osteoclast differentiation and bone resorption. TRANCE activates JNK and NF-kappaB and induces the expression of IL-1, IL-6, IL-12, and IL-15 in dendritic cells.