Purified anti-HDAC1

HDAC1 (histone deacetylase 1) is a 65 kD member of the Class I histone deacetylase family, similar to the yeast RPD3 protein. This nuclear protein operates in concert with histone acetyltransferases to control core histone acetylation in highly conserved lysine residues. HDAC activity has been associated with transcriptional repression and nucleosomal condensation. HDAC1 can be modified by phosphorylation and sumoylation. HDAC1 has been shown to interact with protein phosphatase 1, Rb, MyoD (muscle cells), and the mSin3a co-repressor complex. The Poly6074 antibody has been shown to be useful for Western blotting of human and mouse HDAC1.

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SPECIFICATIONS

Catalog Number

607401

Size

50 microl

Applications

IF, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Clone

Poly6074

Antigen

Synthetic peptides, a.a. 1-5, 433-448, and 467-482

Gene Id

3065

Isotype

Rabbit Polyclonal

Clonality

Polyclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 microl per 5 ml antibody dilution buffer for each mini-gel. For immunofluorescence microscopy: Use a starting dilution of 1:100. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

-20 C

Concentration

Shipping Temp

Ambient RT

Storage Buffer

Upon receipt, store frozen at -20 C.

Alternative Names

Histone deacetylase 1

Regulatory Status

RUO