Purified anti-Fanconi anemia D2 Phospho (Ser222)

Fanconi anemia (also known as Fanconi anemia complementation group D2 (FANCD2)) is a 166 kD member of Fanconi anemia complementation group D. There are multiple isoforms of this nuclear protein including a post-translationally modified form. Activated FANCD2 co-localizes with BRCA1 in ionizing radiation-induced foci and in synaptonemal complexes of meiotic chromosomes. This protein is critical for cellular resistance to DNA cross-linking and cell-cycle arrest after ionizing radiation. DNA damage leads to monoubiquitination of FANCD2 and targeting to nuclear foci. Monoubiquitination occurs during normal cell cycle progression and is required for RAD51 and BRCA1 binding. This protein forms a complex with Fanconi proteins A, C, F, and G. FANCD2 has also been shown to bind to BRCA1, NBS1, and RAD51. The Poly6180 antibody recognizes the phosphorylated human FANCD2 protein (Ser222) and has been shown to be useful for Western blotting.

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SPECIFICATIONS

Catalog Number

618002

Size

200 microl

Applications

WB

Hosts

Rabbit

Reactivities

Hum

Clone

Poly6180

Antigen

Modified peptide

Gene Id

2177

Isotype

Rabbit Polyclonal

Clonality

Polyclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 microl per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

-20 C

Concentration

Shipping Temp

Ambient RT

Storage Buffer

Upon receipt, store frozen at -20 C.

Alternative Names

Fanconi anemia complementation group D2 (FANCD2)

Regulatory Status

RUO