Purified anti-DNA-PKcs

DNA-protein kinase catalytic subunit (DNA-PKcs) also known as DNA-activated kinase is a nuclear 460-470 kD serine threonine kinase involved in double-stranded DNA break repair, VDJ recombination, and transcriptional modulation. DNA-PKcs must bind DNA ends to become active. DNA-PKcs is modified by phosphorylation and has been shown to interact with Ku70/Ku80, KIP, DNA-ligase IV, and XRCC4 proteins. The 7A4 monoclonal antibody has recognizes human DNA-PKcs and has been shown to be useful for immunofluorescence staining and Western blotting.

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SPECIFICATIONS

Catalog Number

612702

Size

100 microg

Applications

IF, WB

Hosts

Mouse

Reactivities

Hum

Clone

7A4

Antigen

Recombinant (partial)

Gene Id

19090

Isotype

Mouse IgG1, kappa

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 5 microg per 5 ml antibody dilution buffer for each mini-gel. For immunofluorescence microscopy: Use a dilution range of 1~4 microg/ml. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

-20 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

Upon receipt, store frozen at -20 C.

Alternative Names

DNA-protein kinase catalytic subunit, DNA-activated protein kinase, DNA-dependent protein kinase

Regulatory Status

RUO