Purified anti-Cyclin E

This rabbit polyclonal antibody recognizes human, mouse, and rat cyclin E also known as Cyclin E1, CCNE, G1/S specific cyclin E1. Cycline E is a nucleus protein, predicted molecular weight 47 kD. Cycline E belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cycline E forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Cyclin E is essential for the control of the cell cycle at the G1/S transition. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. The poly6307 antibody has been shown to be useful for Western blotting, Immunoprecipitation, and Immunohistochemistry.