Purified anti-CHOP (GADD153)

CHOP (also known as growth arrest and DNA-damage-inducible protein GADD153) is a 27 kD member of the C/EBP transcription factor family containing a basic region involved in DNA binding and a leucine zipper domain. This nuclear protein functions as a dimer to inhibit the DNA-binding activity of C/EBP and LAP by forming heterodimers that cannot bind DNA target sequences. CHOP (GADD153) is induced by endoplasmic-reticulum stress and nutrient deprivation. Phosphorylation by p38-MAP kinase enhances activity of this protein while CK2 phosphorylation decreases activity. CHOP (GADD153) has been shown to interact with c-jun, c-fos, C/EBP, and LAP. The Poly6436 antibody has been shown to be useful for Western blotting of the human CHOP protein.

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SPECIFICATIONS

Catalog Number

643601

Size

25 microl

Applications

WB

Hosts

Rabbit

Reactivities

Hum

Clone

Poly6436

Antigen

Peptide

Gene Id

1649

Isotype

Rabbit Polyclonal

Clonality

Polyclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 5 microl per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

-20 C

Concentration

Shipping Temp

Ambient RT

Storage Buffer

Upon receipt, store frozen at -20C.

Alternative Names

Growth arrest and DNA-damage-inducible protein GADD153, DNA-damage inducible transcript 3, C/EBP-homologous protein

Regulatory Status

RUO