Purified anti-Chk2

Chk2 (also known as cell cycle checkpoint kinase 2) is a serine/threonine protein kinase containing an FHA domain. There are two reported isoforms of Chk2 (designated A and B) with molecular weights of approximately 60 kD. Chk2 can be modified by phosphorylation. This nuclear protein controls cell cycle checkpoint and inhibits Cdc25C by phosphorylation. Chk2 prevents entry into mitosis and is upregulated by autophosphorylation in response to DNA damage or other agents that cause replication block. Chk2 has been shown to interact with BRCA1, p53, and Cdc25C. The CHK2909 monoclonal antibody has been shown to be useful for Western blotting of the human Chk2 protein.

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SPECIFICATIONS

Catalog Number

623301

Size

50 microl

Applications

WB

Hosts

Mouse

Reactivities

Hum

Clone

CHK2909

Antigen

Human Chk2 peptide-KLH

Gene Id

11200

Isotype

Mouse IgG1

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 microl per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

-20 C

Concentration

Shipping Temp

Ambient RT

Storage Buffer

Upon receipt, store frozen at -20 C.

Alternative Names

hCds1, CHEK2, RAD53, Checkpoint kinase 2

Regulatory Status

RUO