Purified anti-Cdc25A Phospho (Ser17)

Cdc25A (also know as M-phase inducer phosphatase 1 and dual specificity phosphatase Cdc25A) is a 65 kD MPI phosphatase containing a rhodanese domain. This nuclear protein functions as a dosage-dependent inducer in mitotic control required for the progression of cell cycle. Cdc25A activates Cdc2 by dephosphorylation, dephosphorylates CDK2 in complex with cyclin E. Cdc25A is timulated by cyclins B, downregulated by Chk1 and Cds1/Chk2 phosphorylation. This phosphatase has been shown to interact with Cdc2, cyclin B, Cdk2, Chk1, and Chk2. The Poly6207 antibody recognizes phosphorylated human Cdc25A (Ser17) and has been shown to be useful for Western blotting.

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SPECIFICATIONS

Catalog Number

620702

Size

200 microl

Applications

WB

Hosts

Rabbit

Reactivities

Hum

Clone

Poly6207

Antigen

Modified peptide

Gene Id

993

Isotype

Rabbit Polyclonal

Clonality

Polyclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 microl per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

-20 C

Concentration

Shipping Temp

Ambient RT

Storage Buffer

Upon receipt, store frozen at -20 C.

Alternative Names

M-phase inducer phosphatase 1, Dual specificity phosphatase Cdc25A

Regulatory Status

RUO