Purified anti-Caspase-10

There are two types of apoptotic caspases, initiator (apical) caspases and effector (executioner) caspases. Caspase 10 is one of the initiator caspases that cleave inactive pro-forms of effector caspases, thereby activating them. Four isoforms, namely Caspase-10a,-10 b,-10c,and -10d have been identified. They derived from a single chain polypeptide proenzyme but have different mature large and small subunits by cleavage. After the death ligand-receptor binding, caspade-10 has joined the multimeric Fas/TNF receptor complex and gets cleaved. The cleaved caspase-10 further acts on other effector caspases to initiate the caspase cascade.