Purified anti-CAK (cdk7) Phospho (Ser164/Thr170)

CAK (also known as CDK-activating kinase, CDK7 and cell division protein kinase 7 is a 40 kD nuclear protein that is a member of the serine/threonine family of protein kinases, CDC2/CDKX subfamily. CAK activates cyclin-associated kinases CDC2/CDK1, CDK2, CDK4, CDK6 by threonine phosphorylation and controls cell cycle progression, DNA repair, and RNA polymerase II transcription. CAK is activated by phosphorylation at Thr170 and is inactivated by phosphorylation at Ser164. CAK has been reported to interact with cyclin H and MAT1 to form the CAK complex, the CAK complex then interacts with core-TFIIH to form the TFIIH basal transcription factor. The Poly6324 antibody is useful for immunofluorescence microscopy of human CAK protein.

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SPECIFICATIONS

Catalog Number

632402

Size

100 microl

Applications

IF

Hosts

Rabbit

Reactivities

Hum

Clone

Poly6324

Antigen

Modified peptide

Gene Id

1022

Isotype

Rabbit Polyclonal

Clonality

Polyclonal

Dilutions

Each lot of this antibody is quality control tested by immunofluorescence staining. For immunofluorescence microscopy: Use a dilution range of 1:100~1:400. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

-20 C

Concentration

Shipping Temp

Ambient RT

Storage Buffer

Upon receipt, store frozen at -20 C.

Alternative Names

CDK-activating kinase, CDK7, Cell division protein kinase 7

Regulatory Status

RUO