Purified anti-c-REL

c-Rel is a member of the Rel/NF-kappaB transcription factor family that forms homo or heterodimers with family members such as RelA/p65, RelB, NF-kappaB1/p105, and NF-kappaB2/p100. The NF-kappaB complex is retained in cytoplasm by the inhibitor IkappaB protein in unstimulated cells. Upon activation, IkappaB is degraded via the ubiquitin-proteasome pathway, which results in nuclear translocation of the active NF-kappaB complex. While other NF-kappaB transcription factors are expressed in most cell types, relatively higher levels of c-REL expression are found in hematopoietic cells. c-REL is thought to play key roles in regulating proliferation, differentiation, and survival of B and T lymphocytes.

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SPECIFICATIONS

Catalog Number

655802

Size

100 microg

Applications

WB

Hosts

Mouse

Reactivities

Hum

Clone

2F5A22

Antigen

Partial c-REL recombinant protein (453-587 a.a.)

Gene Id

5966

Isotype

Mouse IgG2b, kappa

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 microg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

Upon receipt, store undiluted at 4C.

Alternative Names

REL, V-Rel Avian Reticuloendotheliosis Viral Oncogene Homolog, Proto-Oncogene C-Rel

Regulatory Status

RUO