Purified anti-c-MAF

c-MAF, originally identified as a homolog of the avian viral oncogen v-maf, belongs to the family of AP-1 basic leucine zipper transcription factors. It forms homodimers or heterodimers with other family members and regulates target genes through binding to the consensus Maf recognition element (MARE) sequence. c-MAF deficient helper T cells have profound defects in producing IL-4 and in differentiating into Th2 cells. Reciprocally, overexpression of c-MAF results in production of IL-4 and attenuated Th1 differentiation. These findings indicate that c-Maf is crucial for IL-4 gene expression and regulation of Th2 differentiation. In addition, studies have also shown that c-Maf is required for the differentiation of Th17 cells as well as the production of IL-10. High expression levels of c-MAF were detected in numerous multiple myeloma cell lines, suggesting that c-MAF might function as an oncogene in multiple myeloma.

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SPECIFICATIONS

Catalog Number

655302

Size

100 microg

Applications

WB

Hosts

Mouse

Reactivities

Hum

Clone

2D9A29

Antigen

Partial c-MAF recombinant protein (64-158 aa)

Gene Id

4094

Isotype

Mouse IgG2b, kappa

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 microg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

Upon receipt, store undiluted at 4C.

Alternative Names

Avian musculoaponeurotic fibrosarcoma (MAF) protooncogene. v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)

Regulatory Status

RUO