Purified anti-BiP

Originally identified as an immunoglobulin heavy chain-binding protein in pre-B cells, BiP was found to be involved in stress responses and also as a molecular chaperone in intracellular protein transport, prevention of protein toxicity and direction of protein folding and assembly in the endoplasmic reticulum. Because so many ER proteins interact transiently with BiP, it may play a key role in monitoring protein transport through the cell.

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SPECIFICATIONS

Catalog Number

644401

Size

25 microg

Applications

WB

Hosts

Rat

Reactivities

Mouse

Clone

76-E6

Antigen

Mouse BiP:u chain complexes

Gene Id

3309

Isotype

Rat IgG2a, kappa

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ? 1.0 microg per 106 cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C.

Alternative Names

the immunoglobulin heavy chain binding protein, GRP-78, GRP78, HSPA5

Regulatory Status

RUO