Purified anti-Bin1

Bridging integrator 1 (Bin1) is a conserved member of the BAR family of genes that have been implicated in diverse cellular processes including endocytosis, cell polarity, programmed cell death, and stress signaling. It is involved in membrane remodeling and is one of the important genes in predicting risk for Alzheimer's disease (AD). Alternative splicing of the gene results in ten transcript variants. Isoforms 1-7 are expressed predominantly in the central nervous system. Isoform 8 is expressed specifically in muscle, and defects in BIN1 cause autosomal recessive myotubular myopathy. Isoforms 9 and 10 are ubiquitously expressed and may act as tumor repressors.

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SPECIFICATIONS

Catalog Number

655602

Size

100 microg

Applications

ELISA, FC, IP, WB

Hosts

Mouse

Reactivities

Hum

Clone

99D

Antigen

Fragment of human Bin1

Gene Id

274

Isotype

Mouse IgG2b

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 4.0 microg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C.

Alternative Names

Amphiphysin 2, AMPHL, SH3P9, Box-Dependent Myc-Interacting Protein 1, Myc Box-Dependent-Interacting Protein 1

Regulatory Status

RUO