Purified anti-BID

BID, a BH3 interacting domain death agonist is a member of the Bcl-2/Bcl-xL family. BID can form a heterodimer with either agonist BAX or antagonist Bcl-2. It is a mediator of mitochondrial damage induced by Caspase-8 (CASP8). After the cleavage by CASP8, the COOH-terminal part translocates to mitochondria and induces cytochrome c release, which in turn activates downstream caspases. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined.

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SPECIFICATIONS

Catalog Number

650501

Size

25 microg

Applications

ELISA, WB

Hosts

Rat

Reactivities

Hum

Clone

1H11

Antigen

Bacteria expressed His tagged full length recombinant protein

Gene Id

637

Isotype

Rat IgG1

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 1.0 microg antibody per ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

Upon receipt, store undiluted at 4C.

Alternative Names

BH3 domain-only protein, BH3 interacting domain death agonist

Regulatory Status

RUO