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Purified anti-beta-catenin

Purified anti-beta-catenin

Cat no: 650901

Supplier: BioLegend
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beta -catenin is a 94 kD nuclear and cytoplasmic protein containing Armadillo repeats. This protein is involved in cell-cell adhesion and the wingless/WNT signaling pathway, and has been implicated as an oncogene. beta-catenin can be modified by glycosylation, phosphorylation, and ubiquitination to target it for degradation. This protein has been shown to interact with E-cadherin, alpha-catenin, axin, APC, GSK-3beta, and Tcf/Lef. Dissociation from axin allows cytoplasmic accumulation. After nuclear translocation, it binds Tcf/Lef.
Catalogue number: 650901
Reactivities: Human, Mouse
Hosts: Mouse
Applications: Immunofluorescence, Western Blot
Size: 25 microg
Clone: 12E4-2
Gene: 12387
Dilutions: Each lot of this antibody has been quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 microg per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: Upon receipt, store undiluted at 4C.
Concentration: 0.5 mg/ml
Antigen: Partial beta-catenin recombinant protein
Isotype: Mouse IgG2a, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: CTNNB1
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