Purified anti-beta-Arrestin-1

The arrestin family consists of four members. Visual arrestins (arrestin 1 and 4) are exclusively expressed in the retina. Beta-arrestin 1 and Beta- arrestin 2, also known as arrestin 2 and arrestin 3, are ubiquitously expressed in most tissues. They are negative regulators of G-protein-coupled receptor (GPCR) signaling. Upon GPCR activation, beta-arrestins trans-locate to the cell membrane and bind to the agonist-occupied receptors and ultimately resulting the receptor internalization and desensitization. Recent evidence suggest that they also function as scaffold proteins to interact with several cytoplasmic proteins and link GPCRs to intracellular signaling pathways.