Purified anti-beta-Arrestin-1

The arrestin family consists of four members. Visual arrestins (arrestin 1 and 4) are exclusively expressed in the retina. Beta-arrestin 1 and Beta- arrestin 2, also known as arrestin 2 and arrestin 3, are ubiquitously expressed in most tissues. They are negative regulators of G-protein-coupled receptor (GPCR) signaling. Upon GPCR activation, beta-arrestins trans-locate to the cell membrane and bind to the agonist-occupied receptors and ultimately resulting the receptor internalization and desensitization. Recent evidence suggest that they also function as scaffold proteins to interact with several cytoplasmic proteins and link GPCRs to intracellular signaling pathways.

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SPECIFICATIONS

Catalog Number

648602

Size

100 microg

Applications

IP, WB

Hosts

Mouse

Reactivities

Hum, Rat, Bov

Clone

25-G10

Antigen

Synthetic peptide specific to human beta-arrestin-1

Gene Id

20215

Isotype

Mouse IgG1, kappa

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 5 - 10 microg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C.

Alternative Names

Arrestin 2

Regulatory Status

RUO