Purified anti-Aurora B Phospho (Thr232)

Aurora B belongs to Serine/threonine kinase family, Aurora subfamily. Predicted molecular weight 39 kD. This kinase is highly expressed in thymus and many cancers and is also expressed in the spleen, lung, testis, colon, placenta and fetal liver. Aurora B is expressed during S and G2/M phase and is up regulated in cancer cells during M phase. Aurora B localizes to centromeres in early mitosisand then the spindle midzone in anaphase and is required for histoneH3 phosphorylation, chromosome alignment, centrosome maturation, activation of the spindle assembly checkpoint and cytokinesis. The Poly6361 antibody recognizes human phospho-Aurora B (Thr232) and has been shown to be useful for immunoflorence staining.

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SPECIFICATIONS

Catalog Number

636102

Size

100 microl

Applications

IF

Hosts

Rabbit

Reactivities

Hum

Clone

Poly6361

Antigen

Modified peptide

Gene Id

9212

Isotype

Rabbit Polyclonal

Clonality

Polyclonal

Dilutions

Each lot of this antibody is quality control tested by immunofluorescence staining. For immunofluorescence microscopy: Use a dilution range of 1:100~1:400. It is recommended that the reagent be titrated. For IHC, use a 1:50 dilution of antibody for staining. Antigen retrieval for IHC of formalin-fixed paraffin-embedded tissue using 0.01 M sodium citrate buffer is recommended.

Storage Temp

-20 C

Concentration

Shipping Temp

Ambient RT

Storage Buffer

Upon receipt, store frozen at -20C.

Alternative Names

AIK2, STK12, AIM1, ARK2, Aurora/IPL1-related kinase 2, Aurora-related kinase 2, Serine/threonine protein kinase 12

Regulatory Status

RUO