Purified anti-a-Adducin

The alpha-adducin protein is a ubiquitously expressed cytoskeletal protein that binds with high affinity to Ca2+/calmodulin and acts as a substrate for protein kinases A and C. alpha-addducin is a 80-120 kD member of the aldolase class II family and adducin subfamily. This protein has three isoforms that interact as heterodimers alpha/beta, and alpha/gamma. The molecular weights for the various isoforms are alpha=120 kD; beta=110kD; gamma=80kD. This protein has been reported to promote the assembly of the spectrin-actin network. Polymorphisms in alpha-adducin are associated with cardiovascular disease and hypertension. alpha-adducin has been reported to interact with calmodulin. When phosphorylated by Rho-kinase, alpha-adducin can regulate membrane ruffling and cell motility. The Poly6170 antibody has been shown to be useful for Western blotting of mouse and human alpha-adducin protein.

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SPECIFICATIONS

Catalog Number

617002

Size

200 microl

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Clone

Poly6170

Antigen

Recombinant (partial)

Gene Id

118

Isotype

Rabbit Polyclonal

Clonality

Polyclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 microl per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

-20 C

Concentration

Shipping Temp

Ambient RT

Storage Buffer

Upon receipt, store frozen at -20 C.

Alternative Names

ADD-1, alpha-Adducin

Regulatory Status

RUO