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PUMA Antibody (OAPB01333)

PUMA Antibody (OAPB01333)

Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.

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SPECIFICATIONS

Size

0.1 mg

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum, Mouse, Rat

Presku

OAPB01333

Target

p53 upregulated modulator of apoptosis

Alternative Names

PUMA (2A9G5); p53 upregulated modulator of apoptosis; bbc3; Bcl-2 binding component 3

SUPPLIER INFO

Aviva Systems Biology Incorporated

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