Reactivities: | Human |
Presku: | AAP64283 |
Size: | 100ug |
Weight: | 47kDa |
Gene: | 9051 |
Format: | Lyophilized powder |
Target: | The protein encoded by this gene binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, negatively affecting CD2-triggered T cell activation. The encoded protein appears to be a scaffold protein and a regulator of the actin cytoskeleton. It has also been shown to bind ABL1, PTPN18, WAS, CD2AP, and PTPN12. Mutations in this gene are a cause of PAPA syndrome. |
Alternative names: | CD2BP1; CD2BP1L; CD2BP1S; H-PIP; PAPAS; PSTPIP |