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Psmd10 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 10) Blocking Peptide (the N terminal of Psmd10)(100ug)

Psmd10 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 10) Blocking Peptide (the N terminal of Psmd10)(100ug)

Supplier: Aviva Systems Biology Incorporated
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This is a synthetic peptide designed for use in combination with anti-Psmd10 Antibody (ARP56481_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Reactivities: Mouse
Presku: AAP56481
Size: 100ug
Weight: 25kDa
Gene: 53380
Format: Lyophilized powder
Target: Psmd10 acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly,Psmd10 is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module By similarity.Psmd10 acts as an oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression of this gene is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Psmd10 regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4.
Alternative names: AW554874
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