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Progesterone Receptor (Ser294) Antibody
ABBIOTEC

Supplier:

ABBIOTEC

Cat no: 252576

Progesterone Receptor (Ser294) Antibody

There is accumulating evidence to suggest that progesterone plays an essential role in the regulation of growth and differentiation of mammary glands and thus may play a key role in breast cancer. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (PR-A and PR-B forms). In most cell conte, Xenopus/Amphibian,ts, the B form functions as a transcriptional activator, whereas the A form functions as a transcriptional inhibitor of steroid hormones. Recently it has been demonstrated that there is differential hormone dependent regulation of the phosphorylation of the A and B forms of the receptor. Treatment of T47D breast cancer cells with progestin agonist increases the phosphorylation of Ser190 and Ser294 with different kinetics. These phosphorylation events may differentially affect the transcriptional activity of the receptor.

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SPECIFICATIONS

Catalog Number

252576

Size

0.1 ml

Applications

IHC

Reactivities

Hum, Mouse, Rabbit

Format

Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by Protein-G affinity chromatography.

P Type

Mouse Monoclonal Antibody,Porcinehosphospecific Antibody

Antigen

KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser294 of human progesterone receptor.

Isotype

Mouse IgG

Accession

P06401

Clonality

608

Additional Info

Progesterone receptor; PR; Nuclear receptor subfamily 3 group C member 3; PGR; NR3C4

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