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proBDNF Human - Recombinant Human Precursor Brain-Derived Neurotrophic Factor (2ug)

proBDNF Human - Recombinant Human Precursor Brain-Derived Neurotrophic Factor (2ug)

Product Introduction: proBDNF (the precursor form of Brain-derived neurotrophic factor) interacts preferentially with p75NTR (the pan-neurotrophin receptor p75) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, while the mature BDNF selectively binds with great affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. Since proneurotrophins and mature neurotrophins bring forth opposite biological effects, proBDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. proBDNF has an important role in negative regulation of neurotrophic actions in the brain.
Product Description: proBDNF Human Recombinant produced in E.Coli is a single, non-glycosylated, non-covalently linked homodimer with each polypeptide chain containing 229 amino acids and having a molecular mass of 52kDa. The proBDNF is purified by proprietary chromatographic techniques.

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SPECIFICATIONS

Size

2ug

Format

Sterile Filtered White lyophilized (freeze-dried) powder.

Presku

OOPA00030

Alternative Names

proBDNF; Precursor Form Brain-derived Neurotrophic Factor.

SUPPLIER INFO

Aviva Systems Biology Incorporated

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