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PPHLN1 (Human) cDNA (1ug)

PPHLN1 (Human) cDNA (1ug)

Supplier: Aviva Systems Biology Incorporated
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The ORF of human PPHLN1 is amplified by PCR using a high fidelity enzyme and sub-cloned into a Prokaryotic expression vector under the control of the tac promoter. The expression of the gene has been confirmed by Western blot using an anti-PPHLN1 polyclonal antibody.
Presku: ANA10527
Size: 1ug
Gene: 51535
Target: The protein encoded by this gene is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. This protein interacts with periplakin, which is known as a precursor of the cornified cell envelope. The cellular localization pattern and insolubility of this protein suggest that it may play a role in epithelial differentiation and contribute to epidermal integrity and barrier formation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.
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