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Products Polyclonal Anti-WNT4
| Catalogue number: | PA2121 |
| Price: | $200.00 |
| Reactivities: | Human, Mouse, Rat |
| Applications: | Western Blot |
| Size: | 100ug/vial |
| Gene: | WNT4 |
| Swiss prot: | P56705 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | Wingless-type MMIV integration site family, member4, is a secreted protein that in humans is encoded by the Wnt4 gene. By fluorescence in situ hybridization, WNT4 gene was mapped to chromosome 1p35, a location consistent with the results of radiation hybrid mapping. The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and embryogenesis. |
| References: | 1. Biason-Lauber, A., De Filippo, G., Konrad, D., Scarano, G., Nazzaro, A., Schoenle, E. J. WNT4 deficiency--a clinical phenotype distinct from the classic Mayer-Rokitansky-Kuster-Hauser syndrome: a case report. Hum. Reprod. 22: 224-229, 2007. 2. Biason-Lauber, A., Konrad, D., Navratil, F., Schoenle, E. J. A WNT4 mutation associated with mullerian-duct regression and virilization in a 46,XX woman. New Eng. J. Med. 351: 792-798, 2004. 3. Garnis, C., Campbell, J., Davies, J. J., MacAulay, C., Lam, S., Lam, W. L. Involvement of multiple developmental genes on chromosome 1p in lung tumorigenesis. Hum. Molec. Genet. 14: 475-482, 2005. |
| Additional info: | A synthetic peptide corresponding to a sequence at the C-terminal of human WNT4, identical to the related mouse and rat sequences. |
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