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Polyclonal Anti-TSHR

Polyclonal Anti-TSHR

Cat no: PA2013

Supplier: Boster Immunoleader
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Rabbit IgG polyclonal antibody for Thyrotropin receptor (TSHR) detection. Tested with WB, IHC-P in Human.
Catalogue number: PA2013
Price: $200.00
Reactivities: Human
Applications: Immunohistochemistry, Western Blot
Size: 100ug/vial
Gene: TSHR
Swiss prot: P16473
Form: Lyophilized
Format: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Storage temp: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.
Scientific background: TSHR (Thyroid-Stimulating Hormone Receptor), also called LGR3. Akamizu et al. (1990) mapped the mouse Tshr gene to chromosome 12 using linkage studies in interspecies backcross mice. The TSH receptor differs from the LHCG receptor by the presence of 2 unique insertions of 8 and 50 amino acids in the extracellular domain. Wadsworth et al. (1990) showed that the 8-amino acid tract near the amino terminus of the TSH receptor is an important site of interaction with both TSH and autoantibodies against the TSH receptor (thyroid-stimulating immunoglobulins, TSI).
References: 1. Akamizu, T., Ikuyama, S., Saji, M., Kosugi, S., Kozak, C., McBride, O. W., Kohn, L. D. Cloning, chromosomal assignment, and regulation of the rat thyrotropin receptor: expression of the gene is regulated by thyrotropin, agents that increase cAMP levels, and thyroid autoantibodies. Proc. Nat. Acad. Sci. 87: 5677-5681, 1990. 2. Dechairo, B. M., Zabaneh, D., Collins, J., Brand, O., Dawson, G. J., Green, A. P., Mackay, I., Franklyn, J. A., Connell, J. M., Wass, J. A. H., Wiersinga, W. M., Hegedus, L., Brix, T., Robinson, B. G., Hunt, P. J., Weetman, A. P., Carey, A. H., Gough, S. C. Association of the TSHR gene with Graves' disease: the first disease-specific locus. Europ. J. Hum. Genet. 13: 1223-1230, 2005. 3. Wadsworth, H. L., Chazenbalk, G. D., Nagayama, Y., Russo, D., Rapoport, B. An insertion in the human thyrotropin receptor critical for high affinity hormone binding. Science 249: 1423-1425, 1990.
Additional info: A synthetic peptide corresponding to a sequence at the N-terminal of human TSHR
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