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Polyclonal Anti-TRPV6

Polyclonal Anti-TRPV6

Cat no: PA1980

Supplier: Boster Immunoleader
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Rabbit IgG polyclonal antibody for Transient receptor potential cation channel subfamily V member 6 (TRPV6) detection. Tested with WB in Human;Rat.
Catalogue number: PA1980
Price: $200.00
Reactivities: Human, Rat
Applications: Western Blot
Size: 100ug/vial
Gene: TRPV6
Swiss prot: Q9H1D0
Form: Lyophilized
Format: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Storage temp: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.
Scientific background: TRPV6 (Transient Receptor Potential Cation Channel Subfamily V Member 6), also known as ECAC2?CAT1 or CATL, a membrane calcium channel which is responsible for the first step in calcium absorption in the intestine. TRPV6 is a member of the Transient receptor potential (TRP) family of membrane proteins. Using FISH, Peng et al. (2000) mapped the TRPV6 gene to chromosome 7q33-q34. Peng et al. (2000) determined that TRPV6 mediates calcium uptake independent of sodium, chloride, and hydrogen; however, calcium influx was higher at alkaline rather than acidic pH. Functional analysis by Peng et al. (2001) indicated that TRPV5 mediates greater calcium uptake than TRPV6. They concluded that TRPV5 and TRPV6 are calcium-selective channels and share a common ancestral gene.
References: 1. Peng, J.-B., Brown, E. M., Hediger, M. A. Structural conservation of the genes encoding CaT1, CaT2, and related cation channels. Genomics 76: 99-109, 2001. 2. Peng, J.-B., Chen, X.-Z., Berger, U. V., Weremowicz, S., Morton, C. C., Vassilev, P. M., Brown, E. M., Hediger, M. A. Human calcium transport protein CaT1. Biochem. Biophys. Res. Commun. 278: 326-332, 2000. 3. Peng, J.-B., Zhuang, L., Berger, U. V., Adam, R. M., Williams, B. J., Brown, E. M., Hediger, M. A., Freeman, M. R. CaT1 expression correlates with tumor grade in prostate cancer. Biochem. Biophys. Res. Commun. 282: 729-734, 2001.
Additional info: A synthetic peptide corresponding to a sequence at the N-terminal of human TRPV6, different from the related rat sequence by one amino acid, and from the mouse sequence by two amino acids.
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