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Products Polyclonal Anti-TIMP1
| Catalogue number: | PA2002 |
| Price: | $200.00 |
| Reactivities: | Mouse |
| Applications: | Western Blot |
| Size: | 100ug/vial |
| Gene: | TIMP1 |
| Swiss prot: | P12032 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | TIMP1 (Tissue Inhibitor of Metalloproteinase 1), is a glycoprotein that is expressed from the several tissues of organisms. This protein is a member of the TIMP family. Using a series of somatic cell hybrids segregating translocation and deletion X chromosomes, Willard et al. (1989) mapped the TIMP locus to Xp11.4-p11.23. By linkage analysis, TIMP was found to be located about 22 cM proximal to OTC. TIMP is identical to the collagenase inhibitor. Human collagenase inhibitor (HCI) appears to play a major role in modulating the activity of interstitial collagenase as well as a number of connective tissue metalloendoproteases. Kenney et al. (2005) found that keratoconus corneas exhibited a 1.8-fold decrease in TIMP1 mRNA and a 2.8-fold decrease in protein compared with normal (physiologic) corneas. |
| References: | 1. Kenney, M. C., Chwa, M., Atilano, S. R., Tran, A., Carballo, M., Saghizadeh, M., Vasiliou, V., Adachi, W., Brown, D. J. Increased levels of catalase and cathepsin V/L2 but decreased TIMP-1 in keratoconus corneas: evidence that oxidative stress plays an role in this disorder. Invest. Ophthal. Vis. Sci. 46: 823-832, 2005. 2. Willard, H. F., Durfy, S. J., Mahtani, M. M., Dorkins, H., Davies, K. E., Williams, B. R. G. Regional localization of the TIMP gene on the human X chromosome: extension of a conserved synteny and linkage group on proximal Xp. Hum. Genet. 81: 234-238, 1989. |
| Additional info: | A synthetic peptide corresponding to a sequence at the C-terminal of mouse TIMP1 |
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