Polyclonal Anti-SLC12A3

Rabbit IgG polyclonal antibody for Solute carrier family 12 member 3 (SLC12A3) detection. Tested with WB, IHC-P, IHC-F in Human;Rat.

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA2170

Size

100?g/vial

Applications

IHC, IHC-Fr, WB

Reactivities

Hum, Rat

Form

Lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

SLC12A3

References

1. Glaudemans, B., Yntema, H. G., San-Cristobal, P., Schoots, J., Pfundt, R., Kamsteeg, E.-J., Bindels, R. J., Knoers, N. V. A. M., Hoenderop, J. G., Hoefsloot, L. H. Novel NCC mutants and functional analysis in a new cohort of patients with Gitelman syndrome. Europ. J. Hum. Genet. 20: 263-270, 2012. \n2. Yang, S.-S., Lo, Y.-F., Yu, I.-S., Lin, S.-W., Chang, T.-H., Hsu, Y.-J., Chao, T.-K., Sytwu, H.-K., Uchida, S., Sasaki, S., Lin, S.-H. Generation and analysis of the thiazide-sensitive Na(+)-Cl(-) cotransporter (Ncc/Slc12a3) Ser707X knockin mouse as a model of Gitelman syndrome. Hum. Mutat. 31: 1304-1315, 2010. \n

Swiss Prot

P55017

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Additional Info

A synthetic peptide corresponding to a sequence at the N-terminal of human SLC12A3, different from the related mouse sequence by three amino acids, and from the related rat sequence by four amino acids.

Scientific Background

Solute carrier family 12 (sodium/chloride transporters), member 3, also called NCCT or TSC, encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. By fluorescence in situ hybridization, this gene is mapped to 16q13. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure.