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Polyclonal Anti-SLC12A3

Polyclonal Anti-SLC12A3

Cat no: PA2170

Supplier: Boster Immunoleader
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Rabbit IgG polyclonal antibody for Solute carrier family 12 member 3 (SLC12A3) detection. Tested with WB, IHC-P, IHC-F in Human;Rat.
Catalogue number: PA2170
Price: $200.00
Reactivities: Human, Rat
Applications: Immunohistochemistry, Immunohistochemistry - frozen, Western Blot
Size: 100?g/vial
Gene: SLC12A3
Swiss prot: P55017
Form: Lyophilized
Format: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Storage temp: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.
Scientific background: Solute carrier family 12 (sodium/chloride transporters), member 3, also called NCCT or TSC, encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. By fluorescence in situ hybridization, this gene is mapped to 16q13. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure.
References: 1. Glaudemans, B., Yntema, H. G., San-Cristobal, P., Schoots, J., Pfundt, R., Kamsteeg, E.-J., Bindels, R. J., Knoers, N. V. A. M., Hoenderop, J. G., Hoefsloot, L. H. Novel NCC mutants and functional analysis in a new cohort of patients with Gitelman syndrome. Europ. J. Hum. Genet. 20: 263-270, 2012. 2. Yang, S.-S., Lo, Y.-F., Yu, I.-S., Lin, S.-W., Chang, T.-H., Hsu, Y.-J., Chao, T.-K., Sytwu, H.-K., Uchida, S., Sasaki, S., Lin, S.-H. Generation and analysis of the thiazide-sensitive Na(+)-Cl(-) cotransporter (Ncc/Slc12a3) Ser707X knockin mouse as a model of Gitelman syndrome. Hum. Mutat. 31: 1304-1315, 2010.
Additional info: A synthetic peptide corresponding to a sequence at the N-terminal of human SLC12A3, different from the related mouse sequence by three amino acids, and from the related rat sequence by four amino acids.
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