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Products Polyclonal Anti-KLF2
| Catalogue number: | PA1919 |
| Price: | $200.00 |
| Reactivities: | Human, Mouse, Rat |
| Applications: | Western Blot |
| Size: | 100ug/vial |
| Gene: | KLF2 |
| Swiss prot: | Q60843 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | KLF2(Krueppel-like factor 2), also known as LKLF (LUNG KRUPPEL-LIKE ZINC FINGER TRANSCRIPTION FACTOR), is a protein that in humans is encoded by the KLF2 gene. Kruppel-like factors (KLFs) are a family of broadly expressed zinc finger transcription factors. KLF2 regulates T-cell trafficking by promoting expression of the lipid-binding receptor S1P1 (S1PR1) and the selectin CD62L. Kozyrev et al. (1999) mapped the KLF2 gene to chromosome 19p13.13-p13.11, close to the KLF1 gene, by radiation hybrid analysis. Wani et al. (1999) mapped the KLF2 gene to 19p13.1 by somatic cell hybrid analysis and FISH. Buckley et al. (2001) showed that expression of LKLF in a T-cell line induced reversible quiescence resulting in marked inhibition of proliferation, decreases in cell size and protein synthesis, and reduced expression of activation markers. They concluded that LKLF functions, in part, by negatively regulating a MYC-dependent pathway. |
| References: | 1. Buckley, A. F., Kuo, C. T., Leiden, J. M. Transcription factor LKLF is sufficient to program T cell quiescence via a c-Myc-dependent pathway. Nature Immun. 2: 698-704, 2001. 2. Kozyrev, S. V., Hansen, L. L., Poltaraus, A. B., Domninsky, D. A., Kisselev, L. L. Structure of the human CpG-island-containing lung Kruppel-like factor (LKLF) gene and its location in chromosome 19p13.11-13 locus. FEBS Lett. 448: 149-152, 1999. 3. Wani, M. A., Conkright, M. D., Jeffries, S., Hughes, M. J., Lingrel, J. B. cDNA isolation, genomic structure, regulation, and chromosomal localization of human lung Kruppel-like factor. Genomics 60: 78-86, 1999. |
| Additional info: | A synthetic peptide corresponding to a sequence at the N-terminal of mouse KLF2, identical to the related rat sequence and different from the related human sequence by one amino acid. |
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