Quick Search
Products Polyclonal Anti-HSD17B4
| Catalogue number: | PA1727 |
| Price: | $200.00 |
| Reactivities: | Human, Mouse, Rat |
| Applications: | Immunohistochemistry, Western Blot |
| Size: | 100ug/vial |
| Gene: | HSD17B4 |
| Swiss prot: | F5HE57 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | The HSD17B4 gene encodes an enzyme involved in peroxisomal fatty acid beta-oxidation. It was first identified as a 17-beta-estradiol dehydrogenase . Peroxisomal beta-oxidation of fatty acids is catalyzed by 3 enzymes: acyl-CoA oxidase; the 'D-bifunctional enzyme,' with enoyl-CoA-hydratase and D-3-hydroxyacyl-CoA dehydrogenase activity, and 3-ketoacyl-CoA thiolase. The D- and L-bifunctional proteins have different substrate specificities. The D-bifunctional protein catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids and also acts in shortening cholesterol for bile acid formation. In contrast, the L-specific bifunctional protein does not have the latter 2 activities. |
| References: | 1.Green, V. L., Speirs, V., Landolt, A. M., Foy, P. M., Atkin, S. L.17-beta-hydroxysteroid dehydrogenase type 1, 2, 3, and 4 expression and enzyme activity in human anterior pituitary adenomas.J. Clin. Endocr. Metab. 84: 1340-1345, 1999. 2.Jiang, L. L., Miyazawa, S., Souri, M., Hashimoto, T.Structure of D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein.J. Biochem. 121: 364-369, 1997. 3.Leenders, F., Dolez, V., Begue, A., Moller, G., Gloeckner, J., de Launoit, Y., Adamski, J.Structure of the gene for the human 17-beta-hydroxysteroid dehydrogenase type IV.Mammalian Genome 9: 1036-1041, 1998. |
| Additional info: | A synthetic peptide corresponding to a sequence at the C-terminal of human HSD17B4, identical to the related rat and mouse sequences. |
Get the Best Promotions
