Polyclonal Anti-HES1

Rabbit IgG polyclonal antibody for Transcription factor HES-1 (HES1) detection. Tested with WB in Human;Mouse;Rat.

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

PA2193

Size

100?g/vial

Applications

WB

Reactivities

Hum, Mouse, Rat

Form

lyophilized

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Gene Id

HES1

References

1. Fukuda, A., Kawaguchi, Y., Furuyama, K., Kodama, S., Horiguchi, M., Kuhara, T., Koizumi, M., Boyer, D. F., Fujimoto, K., Doi, R., Kageyama, R., Wright, C. V. E., Chiba, T.Ectopic pancreas formation in Hes1-knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas. J. Clin. Invest. 116: 1484-1493, 2006.\n2. Wendorff, A. A., Koch, U., Wunderlich, F. T., Wirth, S., Dubey, C., Bruning, J. C., MacDonald, H. R., Radtke, F. Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation. Immunity 33: 671-684, 2010.

Swiss Prot

Q14469

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Additional Info

A synthetic peptide corresponding to a sequence in the middle region of human HES1, identical to the related mouse and rat sequences.

Scientific Background

Transcription factor HES-1, also called HRY or HES-1 is a protein that is encoded by the HES1 gene. This gene belongs to a family of basic helix-loop-helix (bHLH) proteins that are essential for neurogenesis, myogenesis, hematopoiesis, and sex determination. This gene is mapped to 3q29. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. This gene may act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. It may play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.