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Polyclonal Anti-h.EIF2AK3

Polyclonal Anti-h.EIF2AK3

Cat no: PA2026

Supplier: Boster Immunoleader
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Rabbit IgG polyclonal antibody for Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) detection. Tested with WB, ICC in Human.
Catalogue number: PA2026
Price: $200.00
Reactivities: Human
Applications: Immunocytochemistry, Western Blot
Size: 100ug/vial
Gene: EIF2AK3
Swiss prot: Q9NZJ5
Form: Lyophilized
Format: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Storage temp: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.
Scientific background: EIF2AK3 (Eukaryotic Translation Initiation Factor 2-Alpha Kinase 3), also called PEK, is an enzyme that in humans is encoded by the EIF2AK3 gene. By fluorescence in situ hybridization and radiation hybrid analysis, Hayes et al. (1999) mapped the EIF2AK3 gene to chromosome 2p12.Harding et al. (2000) reported that a targeted mutation of the mouse Eif2ak3 gene, which they called Perk, abolished the phosphorylation of eIF2-alpha in response to accumulation of malfolded proteins in the ER, resulting in abnormally elevated protein synthesis and higher levels of ER stress. Using a library of endoribonuclease-prepared short interfering RNAs (esiRNAs), Kittler et al. (2004) identified 37 genes required for cell division, one of which was EIF2AK3.
References: 1. Harding, H. P., Zhang, Y., Bertolotti, A., Zeng, H., Ron, D. Perk is essential for translational regulation and cell survival during the unfolded protein response. Molec. Cell 5: 897-904, 2000. 2. Hayes, S. E., Conner, L. J., Stramm, L. E., Shi, Y. Assignment of pancreatic eIF-2a kinase (EIF2AK3) to human chromosome band 2p12 by radiation hybrid mapping and in situ hybridization. Cytogenet. Cell Genet. 86: 327-328, 1999. 3. Kittler, R., Putz, G., Pelletier, L., Poser, I., Heninger, A.-K., Drechsel, D., Fischer, S., Konstantinova, I., Habermann, B., Grabner, H., Yaspo, M.-L., Himmelbauer, H., Korn, B., Neugebauer, K., Pisabarro, M. T., Buchholz, F. An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division. Nature 432: 1036-1040, 2004.
Additional info: A synthetic peptide corresponding to a sequence at the N-terminal of human EIF2AK3.
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