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Products Polyclonal Anti-h.CYP2U1
| Catalogue number: | PA2022 |
| Price: | $200.00 |
| Reactivities: | Human |
| Applications: | Immunohistochemistry, Western Blot |
| Size: | 100ug/vial |
| Gene: | CYP2U1 |
| Swiss prot: | Q7Z449 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | CYP2U1 (Cytochrome P450, Family 2, Subfamily U, Polypeptide 1), is a protein that in humans is encoded by the CYP2U1 gene. Members of the P450 enzyme family have roles in the tissue-specific conversion of substrates into locally active hormones, vitamins, and signaling molecules, including arachidonic acid derivatives known as eicosanoids. The International Radiation Hybrid Mapping Consortium mapped the CYP2U1 gene to chromosome 4.Chuang et al. (2004) stated that CYP2U1 maps to 4q25. Using recombination experiments in Sf9 insect cells, Chuang et al. (2004) found that CYP2U1 metabolized arachidonic acid, docosahexaenoic acid (DHA), and other long chain fatty acids. Chuang et al. (2004) suggested that CYP2U1 may play a role in brain and immune functions. |
| References: | 1. Chuang, S. S., Helvig, C., Taimi, M., Ramshaw, H. A., Collop, A. H., Amad, M., White, J. A., Petkovich, M., Jones, G., Korczak, B. CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids. J. Biol. Chem. 279: 6305-6314, 2004. 2. Tesson, C., Nawara, M., Salih, M. A. M., Rossignol, R., Zaki, M. S., Al Balwi, M., Schule, R., Mignot, C., Obre, E., Bouhouche, A., Santorelli, F. M., Durand, C. M., and 30 others. Alteration of fatty-acid-metabolizing enzymes affects mitochondrial form and function in hereditary spastic paraplegia. Am. J. Hum. Genet. 91: 1051-1064, 2012. |
| Additional info: | A synthetic peptide corresponding to a sequence at the C-terminal of human CYP2U1. |
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